abstract：BACKGROUND & AIMS:Modulation of dendritic cell (DC) function has been theorized as one of the mechanisms used by hepatitis C virus (HCV) to evade the host immune response and cause persistent infection. METHODS:We used a range of cell and molecular biology techniques to study DC subsets from uninfected and HCV-infecte...

journal_title：Journal of hepatology

authors： Leone P,Di Tacchio M,Berardi S,Santantonio T,Fasano M,Ferrone S,Vacca A,Dammacco F,Racanelli V

更新日期：2014-08-01 00:00:00

abstract：:Human serum albumin (HSA) is one of the most frequent treatments in patients with decompensated cirrhosis. Prevention of paracentesis-induced circulatory dysfunction, prevention of type-1 HRS associated with bacterial infections, and treatment of type-1 hepatorenal syndrome are the main indications. In these indicatio...

journal_title：Journal of hepatology

authors： Arroyo V,García-Martinez R,Salvatella X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) is characterized by increased risk of cardiovascular events and liver-fibrosis. Both could be explained by a procoagulant-imbalance that was surmised but never directly demonstrated. We investigated 113 patients with varying histological liver damage [steatosi...

journal_title：Journal of hepatology

authors： Tripodi A,Fracanzani AL,Primignani M,Chantarangkul V,Clerici M,Mannucci PM,Peyvandi F,Bertelli C,Valenti L,Fargion S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND & AIMS:Number-needed-to-treat is used in assessing the effectiveness of a health-care intervention, and reports the number of patients who need to be treated to prevent one additional bad outcome. Although largely used in medical literature, there are no studies measuring the benefit of liver transplantation...

journal_title：Journal of hepatology

authors： Vitale A,Cucchetti A,Qiao GL,Cescon M,Li J,Ramirez Morales R,Frigo AC,Xia Y,Tuci F,Shen F,Cillo U,Pinna AD

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & AIMS:Although liver fibrosis is an important predictor of outcomes for biliary atresia (BA), postsurgical native liver histology has not been well reported. Here, we retrospectively evaluated postsurgical native liver histology, and developed and assessed a novel scoring system - the BA liver fibrosis (BAL...

journal_title：Journal of hepatology

authors： Tomita H,Masugi Y,Hoshino K,Fuchimoto Y,Fujino A,Shimojima N,Ebinuma H,Saito H,Sakamoto M,Kuroda T

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & AIMS:Given an appreciable risk of adverse-effects, current therapies for chronic hepatitis C virus (HCV) infection pose a dilemma to patients. We explored, via simulation modelling, patient-important benefits of attaining a sustained viral response (SVR). METHODS:We created the HCV Individualised Treatmen...

journal_title：Journal of hepatology

authors： Innes H,Goldberg D,Dusheiko G,Hayes P,Mills PR,Dillon JF,Aspinall E,Barclay ST,Hutchinson SJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic liver disease is characterized by fibrosis that may progress to cirrhosis. Nucleotide oligomerization domain 2 (Nod2), a member of the Nod-like receptor (NLR) family of intracellular immune receptors, plays an important role in the defense against bacterial infection through binding to the lig...

journal_title：Journal of hepatology

authors： Wang L,Hartmann P,Haimerl M,Bathena SP,Sjöwall C,Almer S,Alnouti Y,Hofmann AF,Schnabl B

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & AIMS:FibroTest™ (FT) and Transient Elastography (TE) have been validated as non-invasive markers of METAVIR fibrosis stages from F0 to F4 using biopsy, and as prognostic markers of liver related mortality in patients with chronic hepatitis C. The aim was to extend the validation of FT and TE as markers of ...

journal_title：Journal of hepatology

authors： Poynard T,Vergniol J,Ngo Y,Foucher J,Munteanu M,Merrouche W,Colombo M,Thibault V,Schiff E,Brass CA,Albrecht JK,Rudler M,Deckmyn O,Lebray P,Thabut D,Ratziu V,de Ledinghen V,FibroFrance Study Group.,Epic3 Study Group.,

更新日期：2014-04-01 00:00:00

abstract：:The case for using emergency liver transplantation in acute liver failure was made two decades ago by a series of single centre experiences. The development of models identifying a poor prognosis assisted the selection of patients for liver transplantation but none of these delivers both high sensitivity and specifici...

journal_title：Journal of hepatology

authors： O'Grady J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mechanisms used by cytotoxi...

journal_title：Journal of hepatology

authors： Shivakumar P,Mourya R,Bezerra JA

更新日期：2014-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and its burden is expected to increase further in the next years. In spite of the advances of classical therapies, such as surgery, transplantation, use of radiofrequency and transarterial embolization, the prognosis of this neoplasm ...

journal_title：Journal of hepatology

authors： Giordano S,Columbano A

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND & AIMS:We used longitudinal data from the ANRS CO13 HEPAVIH cohort study of HIV-HCV co-infected individuals to investigate whether polyphenol rich food intake through coffee and/or daily chocolate consumption could play a role in reducing liver enzymes levels. METHODS:Longitudinal data collection included s...

journal_title：Journal of hepatology

authors： Carrieri MP,Lions C,Sogni P,Winnock M,Roux P,Mora M,Bonnard P,Salmon D,Dabis F,Spire B,ANRS CO13 HEPAVIH Study Group.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:The pool of HCV genotype 1 patients likely to be cured by peg-interferon and ribavirin remains to be quantified. METHODS:In 1045 patients treated with peg-interferon and ribavirin, two therapeutic strategies were confronted: the first one evaluated only baseline variables associated with sustained vi...

journal_title：Journal of hepatology

authors： Andriulli A,Di Marco V,Margaglione M,Ippolito AM,Fattovich G,Smedile A,Valvano MR,Calvaruso V,Gioffreda D,Milella M,Morisco F,Felder M,Brancaccio G,Fasano M,Gatti P,Tundo P,Barone M,Cozzolongo R,Angelico M,D'Andrea

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:In the Netherlands, transmission of hepatitis B virus occurs mainly within behavioural high-risk groups, such as in men who have sex with men. Therefore, a vaccination programme has targeted these high-risk groups. This study evaluates the impact of the vaccination programme targeting Amsterdam's larg...

journal_title：Journal of hepatology

authors： van Rijckevorsel G,Whelan J,Kretzschmar M,Siedenburg E,Sonder G,Geskus R,Coutinho R,van den Hoek A

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND & AIMS:Receptor mediated cell death through the activation of caspases has been identified as an important mechanism to control life and death in various tissues and is thus crucial for the maintenance of liver tissue homeostasis. Here we investigated how caspase 8 (Casp8) differentially regulates immune-med...

journal_title：Journal of hepatology

authors： Chaudhary K,Liedtke C,Wertenbruch S,Trautwein C,Streetz KL

更新日期：2013-12-01 00:00:00

abstract：:The addition of protease inhibitors, boceprevir or telaprevir, to peginterferon+ribavirin (PegIFN/RBV) increases the frequency as well as the severity, and hence, clinical relevance of anemia, which has now become one of the major complications associated with triple therapy. Most significant factors associated with a...

journal_title：Journal of hepatology

authors： Romero-Gómez M,Berenguer M,Molina E,Calleja JL

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND & AIMS:Adherence to antiviral treatment is important to achieve sustained virological response (SVR) in chronic hepatitis C (CHC). We evaluated the efficiency of a multidisciplinary support programme (MSP), based on published HIV treatment experience, to increase patient adherence and the efficacy of pegylat...

journal_title：Journal of hepatology

authors： Carrión JA,Gonzalez-Colominas E,García-Retortillo M,Cañete N,Cirera I,Coll S,Giménez MD,Márquez C,Martin-Escudero V,Castellví P,Navinés R,Castaño JR,Galeras JA,Salas E,Bory F,Martín-Santos R,Solà R

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND & AIMS:IL28B polymorphisms, jaundice, decline in HCV-RNA, IP-10, and gender have been proposed to be indicative of spontaneous clearance of acute hepatitis C virus infection. The aim of this study was to define a score enabling the discrimination of patients with spontaneous clearance of HCV from those with ...

journal_title：Journal of hepatology

authors： Beinhardt S,Payer BA,Datz C,Strasser M,Maieron A,Dorn L,Grilnberger-Franz E,Dulic-Lakovic E,Stauber R,Laferl H,Aberle JH,Holzmann H,Krall C,Vogel W,Ferenci P,Hofer H

更新日期：2013-11-01 00:00:00

abstract：:Maturity onset diabetes of the young type 3 (MODY3) and hepatocellular adenomas (HCAs) are associated with mutations in the HNF1A gene. HNF1A codes for the transcription factor HNF1α, which interacts with DNA as a homodimer or a heterodimer with HNF1β, to regulate multiple cellular functions including glucidic metabol...

journal_title：Journal of hepatology

authors： Willson JS,Godwin TD,Wiggins GA,Guilford PJ,McCall JL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:It is widely recognized that in the early stages of liver regeneration after partial hepatectomy, the hepatocytes accumulate a significant amount of lipids. The functional meaning of this transient steatosis and its effect on hepatocellular proliferation are not well defined. In addition, the basic me...

journal_title：Journal of hepatology

authors： Pauta M,Rotllan N,Vales F,Fernandez-Hernando A,Allen RM,Ford DA,Marí M,Jiménez W,Baldán A,Morales-Ruiz M,Fernández-Hernando C

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary atresia (BA) is a pediatric inflammatory disease of the biliary system which leads to cirrhosis and the need for liver transplantation. One theory regarding etiology is that bile duct injury is due to virus-induced autoreactive T cell-mediated inflammation. Regulatory T cell (Treg) abnormaliti...

journal_title：Journal of hepatology

authors： Tucker RM,Feldman AG,Fenner EK,Mack CL

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND & AIMS:A causal relationship between infection, systemic inflammation, and hepatic encephalopathy (HE) has been suggested in cirrhosis. No study, however, has specifically examined, in cirrhotic patients with infection, the complete pattern of clinical and subclinical cognitive alterations and its reversibil...

journal_title：Journal of hepatology

authors： Merli M,Lucidi C,Pentassuglio I,Giannelli V,Giusto M,Di Gregorio V,Pasquale C,Nardelli S,Lattanzi B,Venditti M,Riggio O

更新日期：2013-08-01 00:00:00

abstract：:Pulmonary concerns in liver transplant candidates have intraoperative and outcome implications. Evolving MELD exception policies address transplant priority for problems such as hepatopulmonary syndrome, portopulmonary hypertension, and hemorrhagic hereditary telangiectasia. Other pulmonary issues such as refractory h...

journal_title：Journal of hepatology

authors： Krowka MJ,Wiesner RH,Heimbach JK

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND & AIMS:Several lipid synthesis pathways play important roles in the development and progression of hepatocellular carcinoma (HCC), although the precise molecular mechanisms remain to be elucidated. Here, we show the relationship between HCC progression and alteration of phospholipid composition regulated by ...

journal_title：Journal of hepatology

authors： Morita Y,Sakaguchi T,Ikegami K,Goto-Inoue N,Hayasaka T,Hang VT,Tanaka H,Harada T,Shibasaki Y,Suzuki A,Fukumoto K,Inaba K,Murakami M,Setou M,Konno H

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND & AIMS:Regulatory CD4(+) T cells (Tregs) are considered to affect outcomes of HCV infection, because they increase in number during chronic hepatitis C and can suppress T-cell functions. METHODS:Using microarray analysis, in situ immunofluorescence, ELISA, and flowcytometry, we characterised functional diff...

journal_title：Journal of hepatology

authors： Langhans B,Krämer B,Louis M,Nischalke HD,Hüneburg R,Staratschek-Jox A,Odenthal M,Manekeller S,Schepke M,Kalff J,Fischer HP,Schultze JL,Spengler U

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of th...

journal_title：Journal of hepatology

authors： Ryan MC,Itsiopoulos C,Thodis T,Ward G,Trost N,Hofferberth S,O'Dea K,Desmond PV,Johnson NA,Wilson AM

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND & AIMS:Repair from biliary damages requires the biliary specification of hepatic progenitor cells and the remodeling of ductular reactive structures into branching biliary tubules. We hypothesized that the morphogenetic role of Notch signaling is maintained during the repair process and have addressed this h...

journal_title：Journal of hepatology

authors： Fiorotto R,Raizner A,Morell CM,Torsello B,Scirpo R,Fabris L,Spirli C,Strazzabosco M

更新日期：2013-07-01 00:00:00

abstract：:The ischemic biliary phenotype of hereditary hemorrhagic telangiectasia (HHT) is rare but distinct, with progressive biliary tree ischemia usually resulting in an irreversible secondary sclerosing cholangiopathy. When clinically severe, liver transplant is often indicated. We report three patients with marked HHT asso...

journal_title：Journal of hepatology

authors： Vlachou PA,Colak E,Koculym A,Kirpalani A,Kim TK,Hirschfield GM,Faughnan ME

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND & AIMS:The gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) often depicts non-hypervascular hypointense hepatic nodules during the hepatobiliary phase in patients with hepatocellular carcinoma (HCC). It is unclear whether the presence of thes...

journal_title：Journal of hepatology

authors： Toyoda H,Kumada T,Tada T,Niinomi T,Ito T,Sone Y,Kaneoka Y,Maeda A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:Sustained viral response (SVR) after therapy with interferon-ribavirin (IF-RB) reduces liver-related (LR) complications and mortality in HIV/HCV-co-infected patients. Here, we assess the impact of end-of-treatment response with subsequent relapse (REL) on LR events (LR death, liver decompensation, hep...

journal_title：Journal of hepatology

authors： Berenguer J,Alvarez-Pellicer J,Carrero A,Von Wichmann MA,López-Aldeguer J,Mallolas J,Galindo MJ,Van Den Eynde E,Téllez MJ,Quereda C,Tural C,Sanz J,Barros C,Santos I,Pulido F,Guardiola JM,Ortega E,Rubio R,Jusdado JJ,

更新日期：2013-06-01 00:00:00

abstract：:Tissue stress and cell death result in inflammation even in the absence of pathogens. Such sterile inflammation is dependent on a cytosolic complex of proteins inside immune cells termed the inflammasome. This complex converts two groups of extracellular signals into an inflammatory response via activation of caspase-...

journal_title：Journal of hepatology

authors： Hoque R,Vodovotz Y,Mehal W

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND & AIMS:Nutrients influence non-alcoholic fatty liver disease. Essential fatty acids deficiency promotes various syndromes, including hepatic steatosis, through increased de novo lipogenesis. The mechanisms underlying such increased lipogenic response remain unidentified. METHODS:We used wild type mice and m...

journal_title：Journal of hepatology

authors： Ducheix S,Montagner A,Polizzi A,Lasserre F,Marmugi A,Bertrand-Michel J,Podechard N,Al Saati T,Chétiveaux M,Baron S,Boué J,Dietrich G,Mselli-Lakhal L,Costet P,Lobaccaro JM,Pineau T,Theodorou V,Postic C,Martin PG,Guil

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND & AIMS:We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC). METHODS:A total of 682 HCV-induced LC cases and 1045 CHC patients of Japanese origin were genoty...

journal_title：Journal of hepatology

authors： Urabe Y,Ochi H,Kato N,Kumar V,Takahashi A,Muroyama R,Hosono N,Otsuka M,Tateishi R,Lo PH,Tanikawa C,Omata M,Koike K,Miki D,Abe H,Kamatani N,Toyota J,Kumada H,Kubo M,Chayama K,Nakamura Y,Matsuda K

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND & AIMS:Resveratrol, a polyphenol found in a variety of fruits, exerts a wide range of beneficial effects on the endothelium, regulates multiple vasoactive substances and decreases oxidative stress, factors involved in the pathophysiology of portal hypertension. Our study aimed at evaluating the effects of re...

journal_title：Journal of hepatology

authors： Di Pascoli M,Diví M,Rodríguez-Vilarrupla A,Rosado E,Gracia-Sancho J,Vilaseca M,Bosch J,García-Pagán JC

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND & AIMS:The toll-like receptor 9 (TLR9) agonist IMO-2125 is currently evaluated in clinical trials for chronic hepatitis C therapy. The aim of this study was to investigate the in vivo mode of action of a closely related compound, referred to as immunomodulatory oligonucleotide (IMO). METHODS:We analyzed the...

journal_title：Journal of hepatology

authors： Makowska Z,Blumer T,Duong FH,La Monica N,Kandimalla ER,Heim MH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND & AIMS:Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC(3) included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNα-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. METHO...

journal_title：Journal of hepatology

authors： Poynard T,Bruix J,Schiff ER,Diago M,Berg T,Moreno-Otero R,Lyra AC,Carrilho F,Griffel LH,Boparai N,Jiang R,Burroughs M,Brass CA,Albrecht JK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) have been shown to be involved in many biological processes by affecting their target gene expression. miR-122 has been extensively studied in hepatocarcinogenesis. However, the role of miR-122 in liver fibrosis remains unknown. METHODS:The mRNA expression levels of miR-122, prolyl...

journal_title：Journal of hepatology

authors： Li J,Ghazwani M,Zhang Y,Lu J,Li J,Fan J,Gandhi CR,Li S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND & AIMS:Liver transplant (LT) patients might be overimmunosuppressed as recommendations for tacrolimus trough concentrations (TC) within 4-6 weeks after liver transplantation are set too high (10-15 ng/ml). Early tacrolimus exposure was evaluated in relation to acute rejection and long-term outcomes. METHODS...

journal_title：Journal of hepatology

authors： Rodríguez-Perálvarez M,Germani G,Papastergiou V,Tsochatzis E,Thalassinos E,Luong TV,Rolando N,Dhillon AP,Patch D,O'Beirne J,Thorburn D,Burroughs AK

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND & AIMS:High oxidative stress plays a major role in increasing hepatic vascular resistance in cirrhosis, by facilitating liver fibrosis and by increasing hepatic vascular tone. This study is aimed at investigating whether the use of the novel isoform of recombinant human manganese superoxide dismutase (rMnSOD...

journal_title：Journal of hepatology

authors： Guillaume M,Rodriguez-Vilarrupla A,Gracia-Sancho J,Rosado E,Mancini A,Bosch J,Garcia-Pagán JC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH). However, disease pathogenesis remains largely unknown. microRNA (miRNA or miR) expression has recently been reported to be altered in human NASH, and modulated by urs...

journal_title：Journal of hepatology

authors： Castro RE,Ferreira DM,Afonso MB,Borralho PM,Machado MV,Cortez-Pinto H,Rodrigues CM

更新日期：2013-01-01 00:00:00